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Iowa State University – As part of the “Biotechnology Information Series,” the Iowa State University Web site contains background information on PMPs. Topics explored include production alternatives, commercialization issues, regulatory and ethical issues, other information sources.
The National Science Foundation – The National Science Foundation (NSF), a U.S. government agency whose mission is to “promote the progress of science; to advance the national health, prosperity, and welfare; and to secure the national defense,” provides a primer on plant-made pharmaceuticals (PMPs).
Pharma-Planta Consortium – The Pharma-Planta Project is a consortium of 39 principal scientists from academic and industrial institutions in Europe and South Africa. Pharma-Planta is funded for 5 years, by the European Commission as part of the Sixth Framework Programme in the area of “Plant platforms for immunotherapeutic biomolecule production.”
Purdue University – Purdue University is working in collaboration with Controlled Pharming Ventures, LLC., to develop an enclosed PMP production facility in a converted limestone mine factory in Southern Indiana. Part of this project involves the determination of light level optimization for the growth of PMPs.
Patient Advocacy, Consumer, and other NGOs
The Arthritis Foundation – The Arthritis Foundation is the only national not-for-profit organization that supports the more than 100 types of arthritis and related conditions with advocacy, programs, services and research.
AgBioWorld – AgBioWorld is a non-profit organization that has collected endorsements from more than 3,200 scientists who support the use of biotechnology to improve agriculture in the developing world.
Pew Initiative on Food and Biotechnology – The Pew Initiative on Food and Biotechnology was established in 2001 to be an independent and objective source of credible information on agricultural biotechnology for the public, media and policymakers. Its site contains information on regulation of PMPs, a forum for discussion, and a transcript of a roundtable discussion on regulation of PMPs.
Commercial, Research and Development
Biotechnology Industry Organization (BIO) – BIO provides information, advocacy, and business support for the biotechnology industry. Its section on PMPs contains fact sheets, a link section, and industry information on government regulation.
EuropaBio is the political voice of the biotechnology industry in Europe. This association of bioindustries has some 50 corporate members operating worldwide, 8 associates, 2 regions and 25 national biotechnology associations, representing 1500 small and medium sized biotech companies in Europe.
Biolex Incorporated – Biolex is focused on developing the next generation of recombinant protein production technologies in a plant-based system.
Chlorogen – Through their patented chloroplast technology, Cholorogen develops plant-made drugs and vaccines for the treatment and prevention of human diseases. They also pursue collaborative arrangements for other applications of their technology, such as food and feed, biopolymers and biodefense. By expressing proteins in the chloroplasts of plant cells, Cholorgen is able to greawtly increase the availability of proteins without concern that genes will transfer to other plants via pollen.
Controlled Pharming Ventures, LLC – Controlled Pharming Ventures, LLC is in the process of collaborating with researchers at Purdue University to develop an enclosed PMP production facility in a converted limestone mine factory in Southern Indiana. They intend to act as a vendor to biotech companies developing PMPs.
Diversa Corporation – Diversa is directing its integrated portfolio of technologies to the discovery, evolution, and production of commercially valuable molecules with pharmaceutical applications, such as optimized monoclonal antibodies and orally active drugs, as well as enzymes and small molecules with agricultural, chemical, and industrial applications.
ERA-Plantech – ERA uses proprietary biotechnologies to provide productivity enhancements to plant-based protein-production applicable to plant-made pharmaceuticals (PMPs), plant-made industrial products (PMIPs), crop protection and protein-based nutrition products.
Large Scale Biology – Large Scale Biology Corporation is dedicated to the discovery, analysis, manufacture and commercialization of proteins. LSBC’s activities are built around an integrated suite of ultra-sensitive, industrial-scale technologies created to realize the full commercial and pharmaceutical potential of biology.
Lemnagene – Lemnagene is a company that specializes in the production of recombinant proteins in duckweed.
Medicago – Medicago is a Canadian-based biotechnology company dedicated to PMP and PMIP production.They produce proteins using a unique production system based on alfalfa. Their transient protein production system performed with alfalfa leaves can deliver expression results in less than 3 months, it allows the selection of genetic constructs and is used as a predictive tool. Alfalfa has unique characteristic in that it is well adapted to clonal propagation through somatic embryogenesis or through stem cutting. Moreover alfalfa can produce commercial quantities of recombinant protein in a confined greenhouse environment. Hence Medicago only foresee seed propagation and field production for ultra large scale production of ubiquitous proteins.
Meristem Therapeutics – Meristem Therapeutics has developed a technological platform to ensure the production of recombinant proteins from the gene level up to the production of several tons of purified active substances. The platform is particularly suitable for the large-scale, cost-effective production of antibodies.
Paradigm Genetics – Paradigm Genetics offers a unique systems-biology approach to life sciences discovery; advanced research capabilities in biomarker-enabled drug discovery; Paradigm Array Labs microarray processing services; and, gene-based discovery of novel herbicide and fungicide targets and plant genes important in crop production, pathway engineering of fine chemicals in plants, and high throughput screens for beneficial agricultural compounds.
Phytodyne, Inc. – Phytodyne is working on technology that will allow developers of crops to add traits dependent on multiple genes, place traits in plants with more predictable results, simplify the regulatory process, and eliminate costly and time-consuming steps in development.
ProdiGene – ProdiGene is a private biotechnology company pioneering the use of transgenic plants to produce recombinant proteins for the pharmaceutical, animal health and industrial protein markets. ProdiGene was the first company to produce and market a recombinant protein product from transgenic plants.
Quantum Tubers – Company produced the world’s first full crop of pharmaceutical potatoes containing Hepatitis B Vaccine for Clinical tests using its proprietary biomanufacturing technology for mass multiplication of early generation nuclear seed materials for potato. Company’s cooperation with NASA has produced the world’s only system that will multiply clonal materials in isolation beginning with tissue culture through to physiologically mature minitubers in such a way that millions of zero generation clones are available for field or greenhouse production in the shortest time possible.
SemBioSys, Inc. – SemBioSys uses its proprietary Stratosome Biologics System to overcome the capital requirements, formulation, capacity and cost-of-goods issues facing pharmaceutical developers to help ensure that biologics addressing critical unmet needs are successfully brought to market.
Syngenta – Syngenta is working on early-stage development of six compounds, all proteins, and all in areas that are currently untreatable, including a treatment for psoriasis.
Ventria Bioscience – Ventria Bioscience, has developed a technology platform called ExpressTec, which has produced several proteins that have a variety of applications in human and animal health, including lactoferrin and lysozyme.